The purpose of the present study was to prepare solid dispersion of Tizanidine HCl using different carriers such as PEG 4000 and PEG 6000 in different ratios from (1:1 to 1:5) by fusion method. The Phase solubility profile for PEG 4000 and PEG 6000 was found to be A type solubility curve, showing drug solubility increased with increasing concentration of carriers. The FTIR spectroscopic studies showed that there is absence of well-defined drug carrier interaction and X ray diffraction study (XRD) confirmed that the overall crystalline peak of dispersions was reduced as compared to pure drug. Gibbs free energy (ΔGtr°) values were all negative, indicative the spontaneous nature of drug’s solubilization and they decreases with increasing carrier’s concentration. Dissolution studies using the USP type II apparatus using Paddle method were performed in phosphate buffer pH 6.8 for all solid dispersions and physical mixtures. The dissolution rate increases with increasing the ratio of PEG 6000 (99.98±0.45 % drug release SF15 at 60 mins) as compare to PEG 4000 (94.68±0.79 % drug release SF7 at 60 mins). All solid dispersions & physical mixture showed increased dissolution rate as compared to pure Tizanidine HCl (TZDH) drug. Also, the highest 94.3±0.61 % drug release noted at 30 mins for PEG 6000 (SF15). Finally it was concluded that PEG-6000 shows greater dissolution enhancing capacity than PEG 4000.
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